tert-butyl 1-hydroxypropan-2-ylcarbaMate
N-Boc-D|L-Alaninol
CAS: 147252-84-4
Molecular Formula: C8H17NO3
tert-butyl 1-hydroxypropan-2-ylcarbaMate - Names and Identifiers
tert-butyl 1-hydroxypropan-2-ylcarbaMate - Physico-chemical Properties
| Molecular Formula | C8H17NO3 |
| Molar Mass | 175.23 |
| Density | 1.025 |
| Melting Point | 52-59°C |
| Boling Point | 276.4℃ |
| Flash Point | 118-120°F |
| Solubility | Chloroform |
| Vapor Presure | 0.000597mmHg at 25°C |
| Appearance | Solid |
| Color | Off-white |
| pKa | 12.11±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.45 |
| Physical and Chemical Properties | WGK Germany:2 |
tert-butyl 1-hydroxypropan-2-ylcarbaMate - Risk and Safety
| Risk Codes | R11 - Highly Flammable R25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2926 4.1/PG 3 |
| WGK Germany | 2 |
| Hazard Note | Flammable/Toxic |
| Packing Group | Ⅲ |
tert-butyl 1-hydroxypropan-2-ylcarbaMate - Introduction
N-Boc-D | L-Alaninol is an organic compound whose chemical name is N-tert-butyloxycarbonyl-DL-alaninol. Its properties include:
1. Appearance: White crystalline solid.
2. Molecular formula: C9H17NO3.
3. Molecular weight: 189.23g/mol.
4. Melting Point: about 55-59 degrees Celsius.
5. Solubility: Soluble in alcohols and some organic solvents, such as acetone and dimethylformamide.
N-Boc-D | L-Alaninol has certain applications in organic synthesis, and is often used to introduce resistive protecting groups (Boc groups). Because the compound has high stability, it has good selectivity for the protection of some sensitive groups and the introduction of chiral sites.
N-Boc-D | The preparation method of L-Alaninol is generally realized by the following steps:
1. Dissolve alaninol in dry solvent.
2. Add hydrochloric acid catalyst and stir.
3. Gradually add tert-butoxycarbonyl (Boc2O).
4. After the reaction, the reaction mixture is freed of inorganic salt or inorganic acid residues.
5. Crystallization or extraction using an organic solvent gives the target product.
regarding the safety information of N-Boc-D | L-Alaninol, the following points should be noted:
1. Dark storage: should be stored in a cool, dry and dark environment.
2. Avoid inhalation: in the operation should avoid inhalation of the compound dust or steam. Protective gloves, goggles and face shields should be used.
3. Avoid contact with skin and eyes: Avoid contact with skin and eyes during operation to avoid irritation or damage.
4. Reasonable disposal of waste: the waste and organic solvent separate treatment, comply with the relevant local laws and regulations for waste disposal.
It should be emphasized that this is only a basic introduction, and the specific nature, use, method and safety information also need to refer to relevant literature or consult professionals. If you plan to experiment or use this compound, follow laboratory safety procedures and consult a professional for advice.
1. Appearance: White crystalline solid.
2. Molecular formula: C9H17NO3.
3. Molecular weight: 189.23g/mol.
4. Melting Point: about 55-59 degrees Celsius.
5. Solubility: Soluble in alcohols and some organic solvents, such as acetone and dimethylformamide.
N-Boc-D | L-Alaninol has certain applications in organic synthesis, and is often used to introduce resistive protecting groups (Boc groups). Because the compound has high stability, it has good selectivity for the protection of some sensitive groups and the introduction of chiral sites.
N-Boc-D | The preparation method of L-Alaninol is generally realized by the following steps:
1. Dissolve alaninol in dry solvent.
2. Add hydrochloric acid catalyst and stir.
3. Gradually add tert-butoxycarbonyl (Boc2O).
4. After the reaction, the reaction mixture is freed of inorganic salt or inorganic acid residues.
5. Crystallization or extraction using an organic solvent gives the target product.
regarding the safety information of N-Boc-D | L-Alaninol, the following points should be noted:
1. Dark storage: should be stored in a cool, dry and dark environment.
2. Avoid inhalation: in the operation should avoid inhalation of the compound dust or steam. Protective gloves, goggles and face shields should be used.
3. Avoid contact with skin and eyes: Avoid contact with skin and eyes during operation to avoid irritation or damage.
4. Reasonable disposal of waste: the waste and organic solvent separate treatment, comply with the relevant local laws and regulations for waste disposal.
It should be emphasized that this is only a basic introduction, and the specific nature, use, method and safety information also need to refer to relevant literature or consult professionals. If you plan to experiment or use this compound, follow laboratory safety procedures and consult a professional for advice.
Last Update：2024-04-10 22:29:15
